Why histamine spikes during your period and what to do about it

You track your period diligently you know when the cramps are coming, when to stock up on pads or tampons, and maybe even when your skin might break out.

But what about that stuffy nose, scratchy throat, or pounding headache that hits at the same time?

If these “cold-like” or “allergy” symptoms seem to appear on schedule every month, histamine could be the hidden player behind the scenes.

Hormones, histamine & your period

Histamine is a natural chemical messenger in the body that’s best known for its role in allergic reactions think hay fever, hives, or food sensitivities. But histamine also plays a part in digestion, hormone regulation, and immune signalling.

The catch? Your hormones and histamine talk to each other and during menstruation, the conversation can get loud.

Here’s why:

• Estrogen & Mast Cells
  Estrogen can trigger mast cells (immune cells) to release histamine and also lowers DAO, the enzyme that breaks histamine down.

• Progesterone Drop
  Progesterone helps stabilise mast cells. Right before and during your period, progesterone plummets, leaving histamine release unchecked.

• Prostaglandins
  These inflammatory compounds rise during your bleed to help the uterus contract. They can also amplify histamine’s effects, causing headaches and congestion.

Why histamine flares during bleeding

During menstruation, several changes combine to make histamine symptoms more likely:

• Low hormones: Both estrogen and progesterone are at their lowest point.

• Mast cell activation: Without progesterone’s calming effect, mast cells are more reactive.

• Reduced histamine breakdown: Lower DAO means histamine lingers longer.

• Inflammation spike: High prostaglandins increase inflammation and sensitivity.

• Other triggers: Stress, gut health issues, or a high-histamine diet in the days before your period can make things worse.

Symptoms you might notice

If histamine load is high during your bleed, symptoms can appear in many forms:

• Runny nose or sinus congestion

• Phlegmy throat or post-nasal drip

• Headaches or migraines

• Skin flare-ups or itchiness

• Fatigue or mood changes

• Digestive bloating or cramps beyond the usual PMS

How to support your system

You can’t (and shouldn’t) get rid of histamine completely your body needs it. But you can help your body balance histamine load, especially around your period.

1. Support histamine clearance

Include herbs and nutrients that help stabilise mast cells and aid histamine breakdown:

• Stinging Nettle – Natural antihistamine that helps block histamine receptors and calm allergy-like symptoms.

• Rooibos – Antioxidant-rich and caffeine-free, with compounds like quercetin that reduce histamine release.

• Ginger Root – Anti-inflammatory and mast cell-stabilising, also supports circulation and eases cramps.

• Dandelion Root – Supports liver detoxification to help clear histamine and estrogen metabolites.

2. Calm inflammation & hormones

• Gentle movement like walking or stretching to improve circulation

• Warm compresses or baths to relax muscles and ease cramps

• Prioritise rest and quality sleep

3. Reduce dietary histamine load

• Limit aged cheeses, smoked meats, alcohol, and leftovers during your period

• Opt for fresh-cooked meals with plenty of colourful vegetables

• Include vitamin C and B6-rich foods (kiwifruit, capsicum, poultry, sunflower seeds) to help DAO function

4. Support liver & gut

• Drink bitter teas like dandelion or chamomile

• Include fibre-rich foods to support estrogen clearance

• Maintain hydration to help your body process waste efficiently

A final note

Histamine flares during your period are more common than most people realise. If you’ve been feeling “allergic” or “fluey” on your bleed with no obvious trigger, your cycle may be the missing piece of the puzzle.

By understanding how hormones, inflammation, and histamine interact and supporting your body with the right herbs, nutrition, and lifestyle tools you can make that time of the month a lot more comfortable.